Fluoroaromatic Chemistry and Microreactors
R. D. Chambers
Department of Chemistry, University of Durham, South Road, Durham, DH1 4LN (UK), R.D.Chambers@Durham.ac.uk
Страницы: 31-39
Аннотация
Fluoroaromatic compounds, particularly heterocyclic systems, are important to the pharmaceutical industry and synthetic methods are described for forming carbon-fluorine bonds, by delivering fluorine as fluoride ion and also as an electrophile using elemental fluorine. Fluorinated heterocyclic compounds are very susceptible to nucleophilic attack and the gross factors that affect the orientation of attack are discussed.
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