STRUCTURE, DNA BONDING, AND BIOLOGICAL ACTIVITY OF A NOVEL Pb(II) COMPLEX OF 1,1-BIS(5-(PYRAZIN-2-YL)-1,2,4-TRIAZOL-3-YL) METHANE
E.-J. Gao, B. Meng, J.-Q. Su, T.-T. Peng, Z.-Z. Qi, B. Jia, Y.-H. Feng, M.-C. Zhu
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, P.R. China
enjungao@163.com
Ключевые слова: Pb complex, DNA binding, biological activity
Страницы: 1610-1616
Аннотация
A novel complex [Pb(bptm)(NO3)(H2O)2] (bptm = 1,1-bis(5-(pyrazin-2-yl)-1,2,4-triazol-3-yl) methane) is synthesized and characterized by IR spectroscopy and single crystal X-ray diffraction. Its reactivity with calf thymus DNA and HeLa cell DNA is measured using UV absorption and fluorescence spectroscopies. Gel electrophoresis assay demonstrates the ability of the complex to cleave pBR322 plasmid DNA. Eventually, the complex can suitably dock with a special DNA.
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