Издательство СО РАН

Издательство СО РАН

Адрес Издательства СО РАН: Россия, 630090, а/я 187
Новосибирск, Морской пр., 2

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Яндекс.Метрика

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Поиск по журналу

Журнал структурной химии

2017 год, номер 4

STRUCTURE, AND UREASE INHIBITORY ACTIVITY OF COPPER(II) COMPLEX WITH (E)-3-(2,3-DIHYDROBENZO[B][1,4]DIOXIN-6-YL)ACRYLIC ACID

X.-F. Chen, C.-F. Wang, S. Kong, C. Li, X. Zhou, C.-Y. Zhang, G.-H. Sheng, H.-L. Zhu
Shandong University of Technology, Shandong, P. R. China
hailiang_zhu@163.com
Ключевые слова: caffeic acid, copper(II) complex, crystal structure, urease inhibitory
Страницы: 827-833

Аннотация

A new caffeic acid derivative ((E)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylic acid, HL1)) is synthesized from caffeic acid, followed by the preparation of a Cu(II) complex, [Cu2(L1)4DMSO2]x2DMSO. The structure is determined by single crystal X-ray diffraction, and the urease inhibitory activity of the complex is studied. The results show that IC50 of the complex is 0.56 μmol/L, which is superior to positive control acetohydroxamic acid (AHA, IC50 was 10.95 μmol/l), i.e., the complex has strong inhibitory activity towards urease.

DOI: 10.15372/JSC20170422